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KMID : 1007520150240062235
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Food Science and Biotechnology
2015 Volume.24 No. 6 p.2235 ~ p.2243
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Assessment of the Pectolinarin Content and the Radical Scavenging-linked Antiobesity Activity of Cirsium setidens Nakai Extracts
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Lee Young-Jun
Lee Jin-Ha
Kim Young-Hyun
Kim Jae-Hwan
Yu Seok-Yeong
Kim Dan-Bi
Lee Jong-Seok
Cho Myoung-Lae
Cho Ju-Hyun
Kim Bong-Kyun
Lee Boo-Yong
Lee Ok-Hwan
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Abstract
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Cirsium setidens Nakai contains bioactive compounds that exert biological activities. Method validation for analysis of the pectolinarin content in Cirsium setidens extracts (CSE) and radical scavenging-linked antiobesity activities using 3T3-L1 cells and C57BL/6 mice were performed. The pectolinarin content of CSE was 2.81±0.01 mg/g with a high degree of linearity in calibration curves (R2=0.9999). CSE exhibited free radical-scavenging activities and a reducing power. CSE and pectolinarin inhibited lipid accumulation during adipogenesis of 3T3-L1 cells via down-regulation of adipogenic transcription factors. CSE supplementation suppressed body weight in C57BL/6 mice fed a high fat diet and reduced plasma total cholesterol, triglyceride, insulin, and glucose levels. Pectolinarin-enriched CSE can be considered as a good source of natural antioxidants and antiobesity ingredients.
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KEYWORD
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Cirsium setidens Nakai, pectolinarin, antiobesity, antioxidant activity, peroxisome proliferator-activated receptor γ
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